N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide

Base Information

• Chemical Name: N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide
• CAS No.: 215649-70-0
• Molecular Formula: C10H13 Cl N2 O2
• Molecular Weight: 228.67542
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID90430796
• Nikkaji Number: J985.819I
• Wikidata: Q82244508
• Mol file: 215649-70-0.mol

Synonyms:215649-70-0;N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide;2-(2-HYDROXYETHYLAMINO)-N-(3-CHLOROPHENYL)ACETAMIDE;N-(3-chlorophenyl)-2-(2-hydroxyethylamino)acetamide;DTXSID90430796;AB2868;MFCD09037909;AKOS008958404;SB80005;CS-0323993;A815478;N-(3-Chlorophenyl)-N~2~-(2-hydroxyethyl)glycinamide;N-(3-chlorophenyl)-2-[(2-hydroxyethyl)amino]-acetamide

Chemical Property of N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide

Chemical Property:

• Boiling Point: 470.7±35.0 °C(Predicted)
• PKA: 13.54±0.70(Predicted)
• PSA: 61.36000
• Density: 1.315±0.06 g/cm3(Predicted)
• LogP: 1.32430
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 228.0665554
• Heavy Atom Count: 15
• Complexity: 202

Purity/Quality:

97% ^*data from raw suppliers

N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)NC(=O)CNCCO

Technology Process of N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide

There total 3 articles about N-(3-Chlorophenyl)-2-((2-hydroxyethyl)amino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-N-(3-chlorophenyl)acetamide (2564-05-8) + ethanolamine (141-43-5) → N1-(3-chlorophenyl)-N2-(2-hydroxyethyl)glycinamide (215649-70-0)

Guidance literature:

at 60 ℃;

DOI:10.1016/S0040-4039(98)01670-0

Reference yield:

3-chloro-aniline (108-42-9) → N1-(3-chlorophenyl)-N2-(2-hydroxyethyl)glycinamide (215649-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / isopropyl acetate / 10 °C

2: isopropyl acetate / 1 h / 56 - 62 °C

With potassium carbonate; In Isopropyl acetate;

DOI:10.1002/jhet.5570400206

Reference yield:

3-chloro-aniline (108-42-9) → N1-(3-chlorophenyl)-N2-(2-hydroxyethyl)glycinamide (215649-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: isopropyl acetate, aq. potassium bicarbonate / 5 °C

2: 60 °C

With Isopropyl acetate; potassium hydrogencarbonate;

DOI:10.1016/S0040-4039(98)01670-0

upstream raw materials:

2-chloro-N-(3-chlorophenyl)acetamide

ethanolamine

3-chloro-aniline

Downstream raw materials:

1-(3-chlorophenyl)-4-[1-(4-cyanobenzyl)-5-imidazolylmethyl]-2-piperazinone

N¹-(3-chlorophenyl)-N²-{[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}-N²-(2-hydroxyethyl)glycinamide

1-(3-chlorophenyl)-2-piperazinone hydrochloride