3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

Base Information

Chemical Name:3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine
CAS No.:943601-16-9
Molecular Formula:C₂₂H₃₀F₃N₅O₃
Molecular Weight:469.507
Hs Code.:

Synonyms:3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

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Chemical Property of 3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

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Technology Process of 3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

There total 5 articles about 3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 943601-15-8
2-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzyl methanesulfonate

: 943601-16-9
3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

Guidance literature:: With sodium azide; tetra-(n-butyl)ammonium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 10h;
DOI:10.1021/ol070376i

Reference yield:

: 943601-13-6
2-{[8-(tetrahydropyran-2-yloxy)-octyloxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)}-benzaldehyde

: 943601-16-9
3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

Guidance literature:: Multi-step reaction with 3 steps

1: 822 mg / sodium borohydride / ethanol / 0.17 h / 0 °C

2: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

3: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

With sodium tetrahydroborate; sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol070376i

Reference yield:

: 943601-14-7
C₂₂H₃₁F₃N₂O₄

: 943601-16-9
3-{3-[8-(tetrahydro-2H-pyran-2-yloxy)octyloxy]-4-(azidomethyl)phenyl}-3-trifluoromethyl-3H-diazirine

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 0.17 h / 0 °C

2: 100 percent / sodium azide; tetra-n-butylammonium iodide / dimethylformamide / 10 h / 60 °C

With sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol070376i