Z-D-Ala carbamoylmethyl ester

Base Information

• Chemical Name: Z-D-Ala carbamoylmethyl ester
• CAS No.: 203640-57-7
• Molecular Formula: C₁₃H₁₆N₂O₅
• Molecular Weight: 280.28
• Mol file: 203640-57-7.mol

Synonyms:Z-D-Ala carbamoylmethyl ester

Chemical Property of Z-D-Ala carbamoylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-D-Ala carbamoylmethyl ester

There total 2 articles about Z-D-Ala carbamoylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

glycolamide (598-42-5) + N-benzyloxycarbonyl-D-alanine (26607-51-2) → Z-D-Ala carbamoylmethyl ester (203640-57-7)

Guidance literature:

With Candida antartica lipase B; at 50 ℃; for 16h; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.molcatb.2011.03.012

Reference yield:

N-benzyloxycarbonyl-D-alanine (26607-51-2) + Chloroacetamide (79-07-2) → Z-D-Ala carbamoylmethyl ester (203640-57-7)

Guidance literature:

N-benzyloxycarbonyl-D-alanine; With caesium carbonate; In methanol;

Chloroacetamide; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1039/b004180g

Reference yield: 92.0%

H-L-Leu-NH2 (687-51-4,13079-20-4,13366-40-0,15893-47-7) + Z-D-Ala carbamoylmethyl ester (203640-57-7) → Z-D-Ala-L-Leu-NH2 (18323-56-3)

Guidance literature:

With cross-linked enzyme aggregate of Alcalase; at 50 ℃; for 16h; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.molcatb.2011.03.012

upstream raw materials:

N-benzyloxycarbonyl-D-alanine

Chloroacetamide

glycolamide

Downstream raw materials:

N-benzyloxycarbonyl-D-alanine

Z-D-Ala-L-Leu-NH₂

(R)-tert-butyl 2-((R)-2-(((benzyloxy)carbonyl)amino)propanamido)propanoate

Cbz-D-Ala-L-Pro-NH₂