methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

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Chemical Name:methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate
CAS No.:1417826-09-5
Molecular Formula:C₂₂H₁₅ClF₃N₉O₃
Molecular Weight:545.868
Hs Code.:

Synonyms:methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

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Chemical Property of methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

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Technology Process of methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

There total 4 articles about methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1032667-87-0
methyl 2-amino-5-cyano-3-methylbenzoate

: 1247712-63-5
methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate

: sodium 5-(trifluoromethyl)tetrazol-2-ide

: 1417826-09-5
methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

: 1417826-10-8
methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-1H-tetrazol-1-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

Guidance literature:: methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate; sodium 5-(trifluoromethyl)tetrazol-2-ide; With potassium iodide; In acetone; at 56 ℃; for 9h;

With water; sodium hydroxide; In methanol; at 20 ℃; for 3h;

methyl 2-amino-5-cyano-3-methylbenzoate; Overall yield = 85 %; Overall yield = 4.63 g;

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: N-(2-bromo-4-cyano-6-methylphenyl)-1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxamide

: 1417826-09-5
methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

Guidance literature:: methanol; N-(2-bromo-4-cyano-6-methylphenyl)-1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxamide; With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; triphenylphosphine; Autoclave; Inert atmosphere;

carbon monoxide; at 110 ℃; for 18h; under 7500.75 Torr; Autoclave;

Reference yield:

: 1352319-02-8
1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxylic acid

: 1417826-09-5
methyl 2-({[1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl}-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-Methylpyridine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 °C

1.2: 2 h / 20 - 40 °C

2.1: tributyl-amine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride / Autoclave; Inert atmosphere

2.2: 18 h / 110 °C / 7500.75 Torr / Autoclave

With bis-triphenylphosphine-palladium(II) chloride; 3-Methylpyridine; tributyl-amine; methanesulfonyl chloride; triphenylphosphine; In acetonitrile;