8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

Base Information

Chemical Name:8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril
CAS No.:128232-10-0
Molecular Formula:C₂₈H₂₉N₃O₅
Molecular Weight:487.555
Hs Code.:

Synonyms:8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

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Chemical Property of 8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

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Technology Process of 8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

There total 6 articles about 8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4053-44-5
5-(hydroxymethyl)-8-hydroxyquinoline

: 128232-10-0
8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 55 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h

4: 1.98 g / Ac₂O / 2.5 h / 50 °C

5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

6: 245 mg / butan-1-ol / 20 h / Heating

With acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane; butan-1-ol;
DOI:10.1021/jm00392a006

Reference yield:

: 66546-38-1
8-(benzyloxy)carbostyril-5-carboxaldehyde

: 128232-10-0
8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

2: 245 mg / butan-1-ol / 20 h / Heating

With sodium hydride; dimethyl sulfoxide; In butan-1-ol;
DOI:10.1021/jm00392a006

Reference yield:

: 100-39-0
benzyl bromide

: 128232-10-0
8-(benzyloxy)-5-<2-<<1-(4-nitrophenyl)-2-methylprop-2-yl>amino>-1-hydroxyethyl>carbostyril

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 55 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h

4: 1.98 g / Ac₂O / 2.5 h / 50 °C

5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

6: 245 mg / butan-1-ol / 20 h / Heating

With acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; In dichloromethane; butan-1-ol;
DOI:10.1021/jm00392a006