5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine
CAS No.:950685-74-2
Molecular Formula:C₄₁H₄₂N₂O₁₀
Molecular Weight:722.792
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

There total 1 articles about 5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 14316-61-1
phenoxyacetic anhydride

: 179178-43-9
5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylenethymidine

: 950685-74-2
5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

Guidance literature:: With dmap; In pyridine; at 20 ℃; for 48h;
DOI:10.1002/chem.200601627

Reference yield:

: 950685-74-2
5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

: 950685-75-3
5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-phenoxyacetylen-4-S-(2-cyanoethyl)thiothymidine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyldiisopropylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h

2: 28 mg / N-methylpyrrolidine / 2 h

With 1-Methylpyrrolidine; dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/chem.200601627

Reference yield:

: 950685-74-2
5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-3'-O-phenoxyacetylene thymidine

: 5'-O-(4,4'-dimethoxytrityl)-4'-C-methoxymethylen-4-S-(2-cyanoethyl)thiothymidine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyldiisopropylamine; 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 5 h

2: 28 mg / N-methylpyrrolidine / 2 h

3: 60 percent / conc. NH₄OH / acetonitrile / 14 h

With 1-Methylpyrrolidine; dmap; ammonium hydroxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200601627