5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1427035-25-3
Molecular Formula:C₁₈H₁₅BrF₂N₂O₄S
Molecular Weight:473.295
Hs Code.:

Synonyms:5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Chemical Property of 5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Technology Process of 5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 9 articles about 5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1427035-24-2
5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(methylsulfonamido)benzofuran-3-carboxamide

: 74-88-4
methyl iodide

: 1427035-25-3
5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 1621705-31-4
6-amino-5-bromo-2-(2,4-difluorophenyl)-N-methylbenzofuran-3-carboxamide

: 1427035-25-3
5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1595284-75-5
(6-amino-5-bromo-3-(methylcarbamoyl)benzofuran-2-yl)boronic acid

: 1427035-25-3
5-bromo-2-(2,4-difluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate / N,N-dimethyl-formamide / 3 h / 15 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 0 - 20 °C

2.2: 1 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic trihydrate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;