4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin

Base Information

• Chemical Name: 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin
• CAS No.: 1352616-33-1
• Molecular Formula: C₂₉H₂₆BrNO₇
• Molecular Weight: 580.432
• Mol file: 1352616-33-1.mol

Synonyms:4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin

Chemical Property of 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin

There total 3 articles about 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-bromo-benzaldehyde (1122-91-4) + 4β-amino-4-deoxypodophyllotoxin (155252-35-0) → 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin (1352616-33-1)

Guidance literature:

In ethanol; for 3h; Reflux;

DOI:10.1002/ardp.201100095

Reference yield:

4β-azido-4-deoxypodophyllotoxin (155252-34-9) → 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin (1352616-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / ethyl acetate

2: ethanol / 3 h / Reflux

With palladium on activated charcoal; hydrogen; In ethanol; ethyl acetate;

DOI:10.1002/ardp.201100095

Reference yield:

podofilox (518-28-5) → 4β-(4-bromobenzimidoyl)-4-deoxypodophyllotoxin (1352616-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen azide; boron trifluoride diethyl etherate

2: palladium on activated charcoal; hydrogen / ethyl acetate

3: ethanol / 3 h / Reflux

With hydrogen azide; palladium on activated charcoal; boron trifluoride diethyl etherate; hydrogen; In ethanol; ethyl acetate;

DOI:10.1002/ardp.201100095

upstream raw materials:

4-bromo-benzaldehyde

4β-amino-4-deoxypodophyllotoxin

4β-azido-4-deoxypodophyllotoxin

podofilox

Downstream raw materials:

4β-(4-bromobenzylamino)-4-deoxypodophyllotoxin