(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

Base Information

Chemical Name:(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol
CAS No.:1227514-62-6
Molecular Formula:C₂₁H₃₆O₄Si
Molecular Weight:380.6
Hs Code.:

Synonyms:(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

Suppliers and Price of (3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

There total 1 articles about (3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1227514-61-5
tert-butyl((R)-4-(4-methoxybenzyloxy)-1-((S)-oxiran-2-yl)butan-2-yloxy)dimethylsilane

: 1774-47-6
trimethylsulfoxonium iodide

: 1227514-62-6
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

Guidance literature:: trimethylsulfoxonium iodide; With n-butyllithium; In tetrahydrofuran; at -20 ℃; for 0.666667h; Inert atmosphere;

tert-butyl((R)-4-(4-methoxybenzyloxy)-1-((S)-oxiran-2-yl)butan-2-yloxy)dimethylsilane; In tetrahydrofuran; at -20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.02.093

Reference yield: 95.0%

: 1227514-62-6
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

: 3019-71-4
Trichloroacetyl isocyanate

: 1227514-63-7
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-yl carbamate

Guidance literature:: (3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol; Trichloroacetyl isocyanate; In dichloromethane; at 0 ℃; Inert atmosphere;

With water; potassium carbonate; In methanol; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.tet.2010.02.093

Reference yield: 85.0%

: 1227514-62-6
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol

: 1227514-65-9
(3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)hept-1-en-3-yl hydroxycarbamate

Guidance literature:: (3S,5R)-5-(tert-butyldimethylsilyloxy)-7-(4-methoxybenzyloxy)-hept-1-en-3-ol; With pyridine; 1,1'-carbonyldiimidazole; at 40 ℃; for 4h; Inert atmosphere;

With pyridine; hydroxylamine hydrochloride; at 40 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2010.02.093