(2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol

Base Information

• Chemical Name: (2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol
• CAS No.: 819852-48-7
• Molecular Formula: C₂₁H₂₈O₃SSe
• Molecular Weight: 439.478
• Mol file: 819852-48-7.mol

Synonyms:(2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol

Chemical Property of (2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol

There total 2 articles about (2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

methanol (67-56-1) + ethyl (E)-1-phenylbut-1-en-3-ol (36004-04-3) + C10H13BrOSSe (819852-45-4) → (2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol (819852-48-7) + (2R,3E)-4-phenyl-3-buten-2-ol (62413-47-2) + (S)-trans-4-phenyl-3-buten-2-ol (81176-43-4)

Guidance literature:

C₁₀H₁₃BrOSSe; With silver trifluoromethanesulfonate; In dichloromethane; at 0 ℃;

methanol; ethyl (E)-1-phenylbut-1-en-3-ol; In dichloromethane; at -30 ℃;

DOI:10.1021/ol048001+

Reference yield: 46.0%

methanol (67-56-1) + ethyl (E)-1-phenylbut-1-en-3-ol (36004-04-3) + C11H13F3O4S2Se (438497-46-2) → (2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol (819852-48-7) + (2R,3E)-4-phenyl-3-buten-2-ol (62413-47-2) + (S)-trans-4-phenyl-3-buten-2-ol (81176-43-4)

Guidance literature:

In methanol; dichloromethane; at -30 ℃; for 12h;

DOI:10.1080/10426500590906355

Reference yield: 95.0%

(2R,3S,4R)-4-methoxy-3-(2-methoxy-6-[(1S)-1-(methylsulfanyl)ethyl]phenylselanyl)-4-phenylbutan-2-ol (819852-48-7) → (2R,4S)-4-methoxy-4-phenylbutan-2-ol

Guidance literature:

With 2,2'-azobis(isobutyronitrile); triphenylstannane; In benzene; Heating;

DOI:10.1080/10426500590906355

upstream raw materials:

methanol

ethyl (E)-1-phenylbut-1-en-3-ol

C₁₀H₁₃BrOSSe

C₁₁H₁₃F₃O₄S₂Se

Downstream raw materials:

(2R,3E)-4-phenyl-3-buten-2-ol

1-methoxy-2-{[(2R)-2-methoxy-2-phenylethyl]seleno}-3-[(1S)-1-(methylthio)ethyl]benzene