N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

Base Information

Chemical Name:N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide
CAS No.:145486-16-4
Molecular Formula:C₃₃H₃₈N₄O₆
Molecular Weight:586.688
Hs Code.:

Synonyms:N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

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Chemical Property of N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

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Technology Process of N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

There total 7 articles about N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70680-21-6
4-methyl-2'-nitrobiphenyl

: 145486-16-4
N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-bromosuccinimide, AIBN / CCl₄ / 1.5 h / Heating

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 4 h

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrachloromethane;
DOI:10.1021/jm970816j

Reference yield:

: 577-19-5
2-nitrophenyl bromide

: 145486-16-4
N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 28.05 g / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / propan-2-ol; benzene / 3 h / Heating

2: N-bromosuccinimide, AIBN / CCl₄ / 1.5 h / Heating

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 4 h

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrachloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jm970816j

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 145486-16-4
N-[1-[[(2'-Nitro)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl ]-3-t-butoxycarbonylamino-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 28.05 g / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / propan-2-ol; benzene / 3 h / Heating

2: N-bromosuccinimide, AIBN / CCl₄ / 1.5 h / Heating

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 4 h

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); sodium hydride; In tetrachloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jm970816j