(3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide

Base Information

• Chemical Name: (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide
• CAS No.: 745829-15-6
• Molecular Formula: C₂₂H₂₉N₂OP
• Molecular Weight: 368.459

Synonyms:(3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide

Chemical Property of (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide

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Technology Process of (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide

There total 1 articles about (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S,1'S,1S)-trans-N,N'-bis[(S)-α-phenylethyl]-1,2-diaminocyclohexane (678991-70-3) → (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide (745829-15-6)

Guidance literature:

(1S,2S,1'S,1"S)-trans-N,N'-bis[(S)-α-phenylethyl]-1,2-diaminocyclohexane; With triethylamine; phosphorus trichloride; In toluene;

With water; triethylamine; In toluene; Further stages.;

DOI:10.1016/j.tetlet.2004.04.027

Reference yield: 65.0%

benzaldehyde (100-52-7) + (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide (745829-15-6) → (3aS,7aS)-1-{2-oxo-1,3-bis[(S)-1-phenylethyl]perhydro-1,3,2λ5-benzodiazaphosphol-2-yl}-1-phenylmethanol

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -60.15 ℃; for 5.5h;

DOI:10.1107/S0108270104008492

Reference yield:

4-methoxy-benzaldehyde (123-11-5) + (3aS,7aS)-1,3-Bis-((S)-1-phenyl-ethyl)-octahydro-benzo[1,3,2]diazaphosphole 2-oxide (745829-15-6) → (S)-(4-Methoxy-phenyl)-[(3aS,7aS)-2-oxo-1,3-bis-((S)-1-phenyl-ethyl)-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl]-methanol + (R)-(4-Methoxy-phenyl)-[(3aS,7aS)-2-oxo-1,3-bis-((S)-1-phenyl-ethyl)-octahydro-2λ5-benzo[1,3,2]diazaphosphol-2-yl]-methanol

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2004.04.027

upstream raw materials:

(1S,2S,1'S,1S)-trans-N,N'-bis[(S)-α-phenylethyl]-1,2-diaminocyclohexane

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