4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

Base Information

Chemical Name:4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine
CAS No.:1351523-97-1
Molecular Formula:C₂₀H₁₇N₅S
Molecular Weight:359.454
Hs Code.:

Synonyms:4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

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Chemical Property of 4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

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Technology Process of 4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

There total 4 articles about 4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1229383-84-9
4-(2-bromophenyl)-N-cyclopropylthiazol-2-amine

: 433922-57-7
5-bromo-2-(1H-pyrazol-1-yl)pyridine

: 1351523-97-1
4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

Guidance literature:: 4-(2-bromophenyl)-N-cyclopropylthiazol-2-amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h; Inert atmosphere;

5-bromo-2-(1H-pyrazol-1-yl)pyridine; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; for 6h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2018.09.015

Reference yield:

: 49851-55-0
2,2'-dibromoacetophenone

: 1351523-97-1
4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 2 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

2.3: 6 h / Inert atmosphere; Reflux

With n-butyllithium; In tetrahydrofuran; ethanol; hexane; 1.1: |Hantzsch Thiazole Synthesis / 2.3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2018.09.015

Reference yield:

: 2142-69-0
2-bromophenyl methyl ketone

: 1351523-97-1
4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)-N-cyclopropylthiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; bromine / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2.1: ethanol / 2 h / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

3.3: 6 h / Inert atmosphere; Reflux

With aluminum (III) chloride; n-butyllithium; bromine; In tetrahydrofuran; ethanol; hexane; 2.1: |Hantzsch Thiazole Synthesis / 3.3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2018.09.015