N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

Base Information

Chemical Name:N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide
CAS No.:958358-19-5
Molecular Formula:C₂₄H₂₈ClN₅O₃SSi
Molecular Weight:530.123
Hs Code.:

Synonyms:N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

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Chemical Property of N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

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Technology Process of N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

There total 4 articles about N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958357-82-9
6-(5-amino-6-chloropyridin-3-yl)-5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridine

: 98-09-9
benzenesulfonyl chloride

: 958358-19-5
N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

Guidance literature:: 6-(5-amino-6-chloropyridin-3-yl)-5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridine; benzenesulfonyl chloride; With pyridine; at 0 - 20 ℃; for 24h;

With macroporous polystyrene carbonate resin; In methanol; water; for 23h;

With acetic acid; In methanol;

Reference yield:

: 588729-99-1
3-amino-5-bromo-2-chloropyridine

: 958358-19-5
N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2.5 h / 80 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; ethanol; water / 8 h / 80 °C

3.1: pyridine / 24 h / 0 - 20 °C

3.2: macroporous polystyrene carbonate resin / 23 h

With pyridine; potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 958358-19-5
N-{2-chloro-5-[5-methyl-3-(2-trimethylsilylethoxymethyl)-3H-imidazo[4,5-b]pyridin-6-yl]pyridin-3-yl}benzenesulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 - 20 °C

1.2: 20 h / 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; ethanol; water / 8 h / 80 °C

3.1: pyridine / 24 h / 0 - 20 °C

3.2: macroporous polystyrene carbonate resin / 23 h

With pyridine; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;