Technology Process of N-[3-methyl-3-(4-nitro-phenyl)-butyl]-acetamide
There total 16 articles about N-[3-methyl-3-(4-nitro-phenyl)-butyl]-acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 1 - 16h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: aluminum (III) chloride / 17.33 h / 0 - 20 °C
2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C
3: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C
4: sulfuric acid; potassium nitrate / dichloromethane / 16 h / 50 °C
5: borane-THF / tetrahydrofuran / 16.25 h / 80 °C
6: triethylamine / dichloromethane / 1 - 16 h / 0 - 20 °C
With
aluminum (III) chloride; borane-THF; oxalyl dichloride; sulfuric acid; ammonium hydroxide; potassium nitrate; triethylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C
2: ammonium hydroxide / dichloromethane / 1 h / 0 - 20 °C
3: sulfuric acid; potassium nitrate / dichloromethane / 16 h / 50 °C
4: borane-THF / tetrahydrofuran / 16.25 h / 80 °C
5: triethylamine / dichloromethane / 1 - 16 h / 0 - 20 °C
With
borane-THF; oxalyl dichloride; sulfuric acid; ammonium hydroxide; potassium nitrate; triethylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; dichloromethane;
