(S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester

Base Information

• Chemical Name: (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester
• CAS No.: 1095089-26-1
• Molecular Formula: C₁₆H₂₂INO₅
• Molecular Weight: 435.259

Synonyms:(S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester

Chemical Property of (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester

There total 3 articles about (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-(tert-butyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid (1095089-24-9) + methyl iodide (74-88-4) → (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester (1095089-26-1)

Guidance literature:

With potassium carbonate; In acetone; at 56 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b811583d

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester (1095089-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 16.17 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / acetone / 20 h / Inert atmosphere; Reflux

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; acetone;

DOI:10.1002/asia.201000908

Reference yield:

(S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride (1095089-33-0) → (S)-2-(tert-butyloxycarbonyl)amino-3-(2-methoxy-5-iodphenyl)propionic acid methyl ester (1095089-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 16.17 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / acetone / 20 h / Inert atmosphere; Reflux

With potassium carbonate; sodium hydroxide; In 1,4-dioxane; water; acetone;

DOI:10.1002/asia.201000908

upstream raw materials:

(S)-2-(tert-butyloxycarbonylamino)-3-(5-iodo-2-methoxyphenyl)-propionic acid

methyl iodide

di-tert-butyl dicarbonate

(S)-2-amino-3-(5'-iodo-2'-methoxyphenyl)propanoic acid hydrochloride

Downstream raw materials:

(S)-2-tert-butyloxycarbonylamino-3-[2’-methoxy-5’-(4’’,4’’,5’’,5’’-tetramethyl 1’’,3’’,2’’-dioxaborolane-2’’-yl)phenyl]-propionic acid methylester

(2S,2’’’S)-2-(benzyloxcarbonylamino)-3-(4’,4’’-bis-methoxy-3’’-[tert-butyloxycarbonylamino-2’’’-methoxycarbonylethyl]-biphenyl-3’-yl)-propionic acid

C₄₉H₇₀N₆O₁₂Si

(4S,7S,10S,2’R)-10-benzyoxycarbonylamino-1¹,2¹-bis-methoxy-7-[3’-azido-2’-(tert-butyldimethyl-silyloxy)propyl]-5,8-diaza-6,9-dioxo-1,2(4,2)-dibenzenacycloundecaphane-4-methyl carboxylate

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