4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:146948-78-9
Molecular Formula:C₃₀H₃₂ClN₅O₇S
Molecular Weight:642.132
Hs Code.:

4-<<2'-<N-(tert-butoxycarbonyl)sulfamoyl>biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Synonyms:4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 9 articles about 4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146949-06-6
ethyl N-carbethoxy-valerimidate

: 146948-78-9
4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 74 percent / anisole, TFA / 48 h / Ambient temperature

4: 1.) NaH / 1.) THF, 50 deg C, 4 h, 2.) THF, 60 deg C, 48 h

With sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In toluene;
DOI:10.1021/jm00052a006

Reference yield:

: 75-09-2
dichloromethane

: 24424-99-5
di-tert-butyl dicarbonate

: 146949-05-5
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

: 146948-78-9
4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: In methanol;

Reference yield:

: 100367-78-0
(2-bromo-5-nitrophenyl)hydrazine

: 146948-78-9
4-<<2'-biphenyl-4-yl>methyl>-5-n-butyl-2-<2-chloro-5-nitrophenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 32 percent / KF, CuI / dimethylformamide / 12 h / 120 °C

4: 74 percent / anisole, TFA / 48 h / Ambient temperature

5: 1.) NaH / 1.) THF, 50 deg C, 4 h, 2.) THF, 60 deg C, 48 h

With potassium fluoride; copper(l) iodide; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00052a006