tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

Base Information

Chemical Name:tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate
CAS No.:1018674-52-6
Molecular Formula:C₂₂H₃₃NO₄
Molecular Weight:375.508
Hs Code.:

Synonyms:tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

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Chemical Property of tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

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Technology Process of tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

There total 4 articles about tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 21691-53-2
L-leucine tert-butyl ester

: 156781-13-4
methyl 4-formylmethylcinnamate

: 1018674-52-6
tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 335164-35-7
(2E)-3-[4-(2-hydroxyethyl)phenyl]acrylate

: 1018674-52-6
tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 72 h / 20 °C

With sodium tris(acetoxy)borohydride; Dess-Martin periodane; In dichloromethane;

Reference yield:

: 73401-74-8
4-hydroxymethylphenylacetic acid

: 1018674-52-6
tert-butyl N-(2-{4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]phenyl}ethyl)-L-leucinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: manganese(IV) oxide / chloroform / 18 h / 50 °C

2.1: potassium carbonate / water / 72 h / 0 - 20 °C

2.2: pH 1

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

3.2: 1 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 72 h / 20 °C

With manganese(IV) oxide; oxalyl dichloride; sodium tris(acetoxy)borohydride; potassium carbonate; Dess-Martin periodane; N,N-dimethyl-formamide; In dichloromethane; chloroform; water;