(3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Base Information

Chemical Name:(3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one
CAS No.:100516-59-4
Molecular Formula:C₂₈H₂₉NO₄
Molecular Weight:443.543
Hs Code.:

Synonyms:(3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Suppliers and Price of (3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

There total 7 articles about (3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 100570-94-3
(5S,6R)-3-Bromo-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 100516-59-4
(3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/ja00265a053

Reference yield: 48.0%

: 109-72-8,29786-93-4
n-butyllithium

: 111934-06-6
(3S,5S,6R)-4-(benzyloxycarbonyl)-3-bromo-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 100516-59-4
(3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.833333h;
DOI:10.1021/ja00213a031

Reference yield:

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 100516-59-4
(3S,5S,6R)-4-(benzyloxycarbonyl)-3-butyl-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / tetrahydrofuran / 25 °C

2: NaHCO₃ / CH₂Cl₂; H₂O

3: p-TsOH / benzene / Heating

4: NBS / CCl₄ / 0.58 h / Heating

5: 48 percent / tetrahydrofuran / 0.5 h / -78 °C

With N-Bromosuccinimide; sodium hydrogencarbonate; triethylamine; toluene-4-sulfonic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; benzene;
DOI:10.1021/ja00265a053