3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

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Chemical Name:3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid
CAS No.:943345-22-0
Molecular Formula:C₂₈H₂₃N₃O₄
Molecular Weight:465.508
Hs Code.:

Synonyms:3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

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Chemical Property of 3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

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Technology Process of 3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

There total 5 articles about 3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

: 943345-21-9
3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

: 943345-22-0
3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

Guidance literature:: 3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 20 - 50 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 4254-17-5
4-methoxybenzoin

: 943345-22-0
3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice

2.1: acetic anhydride / 0 °C

2.2: 10 - 130 °C

3.1: trichlorophosphate / 1 h / Reflux

3.2: 55 - 75 °C / pH 9

4.1: 1.5 h / 150 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

With water; acetic anhydride; diethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 14774-62-0
2-amino-4-(4-methoxyphenyl)-5-phenylfuran-3-carbonitrile

: 943345-22-0
3-(3-{[5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic anhydride / 0 °C

1.2: 10 - 130 °C

2.1: trichlorophosphate / 1 h / Reflux

2.2: 55 - 75 °C / pH 9

3.1: 1.5 h / 150 °C

4.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 - 50 °C

With water; acetic anhydride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran;