3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

Base Information

Chemical Name:3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester
CAS No.:943345-21-9
Molecular Formula:C₂₉H₂₅N₃O₄
Molecular Weight:479.535
Hs Code.:

Synonyms:3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

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Chemical Property of 3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

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Technology Process of 3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

There total 4 articles about 3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.7%

: 943230-31-7
4-chloro-5-(4-methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidine

: 35418-08-7
methyl 3-(3-aminophenyl)propanoate

: 943345-21-9
3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

Guidance literature:: at 150 ℃; for 1.5h;

Reference yield:

: 4254-17-5
4-methoxybenzoin

: 943345-21-9
3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Cooling with ice

2.1: acetic anhydride / 0 °C

2.2: 10 - 130 °C

3.1: trichlorophosphate / 1 h / Reflux

3.2: 55 - 75 °C / pH 9

4.1: 1.5 h / 150 °C

With acetic anhydride; diethylamine; trichlorophosphate; In N,N-dimethyl-formamide;

Reference yield:

: 14774-62-0
2-amino-4-(4-methoxyphenyl)-5-phenylfuran-3-carbonitrile

: 943345-21-9
3-(3-{[5-(4-Methoxyphenyl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]amino}phenyl)propanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic anhydride / 0 °C

1.2: 10 - 130 °C

2.1: trichlorophosphate / 1 h / Reflux

2.2: 55 - 75 °C / pH 9

3.1: 1.5 h / 150 °C

With acetic anhydride; trichlorophosphate;