(1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

Base Information

Chemical Name:(1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one
CAS No.:868843-54-3
Molecular Formula:C₂₄H₃₇NO₂
Molecular Weight:371.563
Hs Code.:

Synonyms:(1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

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Chemical Property of (1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

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Technology Process of (1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

There total 4 articles about (1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 544711-65-1
(4R,5R)-5-(2,3-dihydroxypropyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 868843-54-3
(1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

Guidance literature:: (4R,5R)-5-(2,3-dihydroxypropyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one; With dimethylsulfide borane complex; In tetrahydrofuran; for 5.5h; Heating;

With triethylamine; palladium on activated charcoal; In methanol; at 20 ℃;

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃;
DOI:10.1021/jo050983o

Reference yield:

: 102225-88-7
(-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol

: 868843-54-3
(1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydride / tetrahydrofuran / 2 h

1.2: 79 percent / tetrahydrofuran / 2.5 h / -50 - 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -90 - -40 °C

2.2: HMPA / tetrahydrofuran; hexane / -40 - 0 °C

3.1: borane-dimethyl sulfide complex / tetrahydrofuran / 5.5 h / Heating

3.2: triethylamine / Pd/C / methanol / 20 °C

3.3: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / -60 - 20 °C

With n-butyllithium; dimethylsulfide borane complex; potassium hydride; In tetrahydrofuran; hexane; 4.3: Swern oxidation;
DOI:10.1021/jo050983o

Reference yield:

: 220416-57-9
2-((1S)-1-((1E)-1,2-dichloroethenyloxy)ethyl)-1,3,5-triisopropylbenzene

: 868843-54-3
(1R,7aR)-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]hexahydropyrrolizin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -90 - -40 °C

1.2: HMPA / tetrahydrofuran; hexane / -40 - 0 °C

2.1: borane-dimethyl sulfide complex / tetrahydrofuran / 5.5 h / Heating

2.2: triethylamine / Pd/C / methanol / 20 °C

2.3: oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / -60 - 20 °C

With n-butyllithium; dimethylsulfide borane complex; In tetrahydrofuran; hexane; 3.3: Swern oxidation;
DOI:10.1021/jo050983o