tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane

Base Information

• Chemical Name: tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane
• CAS No.: 1449115-47-2
• Molecular Formula: C₁₄H₂₄OSi
• Molecular Weight: 236.429
• Mol file: 1449115-47-2.mol

Synonyms:tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane

Chemical Property of tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane

Chemical Property:

Purity/Quality:

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Technology Process of tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane

There total 1 articles about tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trifluoro-methanesulfonic acid 4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl ester (865869-24-5) + acetylenemagnesium bromide (4301-14-8) → tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane (1449115-47-2)

Guidance literature:

With cobalt(III) acetylacetonate; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ja405043g

Reference yield: 89.0%

4-toluenesulfonyl azide (941-55-9) + tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane (1449115-47-2) → 6-((tert-butyldimethylsilyl)oxy)-1-tosyl-1H-indole (1449115-31-4)

Guidance literature:

4-toluenesulfonyl azide; tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane; With copper(I) thiophene-2-carboxylate; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere; Sealed tube;

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In 1,2-dichloro-ethane; at 60 ℃; Inert atmosphere; Sealed tube;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dichloro-ethane; at 60 ℃; Inert atmosphere; Sealed tube;

DOI:10.1021/ja405043g

Reference yield: 79.0%

4-toluenesulfonyl azide (941-55-9) + tert-butyl((4-ethynylcyclohex-3-en-1-yl)oxy)dimethylsilane (1449115-47-2) → 4-(4-((tert-butyldimethylsilyl)oxy)cyclohex-1-en-1-yl)-1-tosyl-1H-1,2,3-triazole (1449115-37-0)

Guidance literature:

With copper(I) thiophene-2-carboxylate; In toluene; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja405043g

upstream raw materials:

trifluoro-methanesulfonic acid 4-(tert-butyl-dimethyl-silanyloxy)-cyclohex-1-enyl ester

acetylenemagnesium bromide

Downstream raw materials:

6-((tert-butyldimethylsilyl)oxy)-1-tosyl-1H-indole

4-(4-((tert-butyldimethylsilyl)oxy)cyclohex-1-en-1-yl)-1-tosyl-1H-1,2,3-triazole