N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide

Base Information

• Chemical Name: N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide
• CAS No.: 1354657-36-5
• Molecular Formula: C₂₄H₃₀N₂O₅S
• Molecular Weight: 458.579
• Mol file: 1354657-36-5.mol

Synonyms:N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide

Chemical Property of N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide

There total 9 articles about N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

formic acid (64-18-6) + N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]hydroxylamine (1354657-78-5) → N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide (1354657-36-5)

Guidance literature:

With acetic anhydride; In tetrahydrofuran; at 20 ℃; for 4h;

Reference yield:

{4-[(E)-2-(4-but-2-ynyloxybenzenesulfonyl)vinyl]benzyl}diethylamine (1354657-77-4) → N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide (1354657-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine / tetrahydrofuran / 25 h / 20 °C

2: acetic anhydride / tetrahydrofuran / 4 h / 20 °C

With hydroxylamine; acetic anhydride; In tetrahydrofuran;

Reference yield:

tert-butyl {4-[2-(4-but-2-ynyloxybenzenesulfonyl)vinyl]benzyl}carbamate (1354657-75-2) → N-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-(4-diethylaminomethylphenyl)ethyl]-N-hydroxyformamide (1354657-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / methanol / 1.5 h / 20 °C

3: hydroxylamine / tetrahydrofuran / 25 h / 20 °C

4: acetic anhydride / tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; hydroxylamine; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol;

upstream raw materials:

tert-butyl {4-[2-(4-but-2-ynyloxybenzenesulfonyl)acetyl]benzyl}carbamate

tert-butyl {4-[2-(4-but-2-ynyloxybenzenesulfonyl)vinyl]benzyl}carbamate

tert-butyl {4-[2-(4-but-2-ynyloxybenzenesulfonyl)-1-hydroxyethyl]benzyl}carbamate

4-[(E)-2-(4-But-2-ynyloxybenzenesulfonyl)vinyl]benzylamine hydrochloride