4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

Base Information

Chemical Name:4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile
CAS No.:1240914-98-0
Molecular Formula:C₂₀H₂₅N₃O
Molecular Weight:323.438
Hs Code.:

Synonyms:4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

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Chemical Property of 4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

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Technology Process of 4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

There total 10 articles about 4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 557-21-1
zinc(II) cyanide

: 1240914-95-7
((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

: 1240914-98-0
4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

Guidance literature:: With zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 20h; Inert atmosphere;

Reference yield:

: 1123620-89-2,2137065-16-6
(1S,2S)-2-(4-bromophenyl)cyclopropanecarboxylic acid

: 1240914-98-0
4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 0 °C

2: zinc / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1-methyl-pyrrolidin-2-one / 44 h / 100 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 170033-47-3
(R)-tert-butyl 2-methylpiperazine-1-carboxylate

: 1240914-98-0
4-((1S, 2S)-2-((R)-4-cyclobutyl-2-methylpiperazine-1-carbonyl)cyclopropyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / ethanol / 1 h / 20 °C

1.2: 4.5 h

1.3: 5.5 h / 10 - 48 °C

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 0 °C

3.1: zinc / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / 1-methyl-pyrrolidin-2-one / 44 h / 100 °C / Inert atmosphere

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide;