((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone
CAS No.:1240914-95-7
Molecular Formula:C₁₉H₂₅BrN₂O
Molecular Weight:377.324
Hs Code.:

Synonyms:((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

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Chemical Property of ((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

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Technology Process of ((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

There total 8 articles about ((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (R)-1-cyclobutyl-3-methylpiperazine dihydrochloride

: 1123620-89-2,2137065-16-6
(1S,2S)-2-(4-bromophenyl)cyclopropanecarboxylic acid

: 1240914-95-7
((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: 4209-02-3
1-(4-bromophenyl)-2-chloroethan-1-one

: 1240914-95-7
((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylsulfide borane complex / (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene; 2-methyltetrahydrofuran / 4 h / 40 - 45 °C / Industry scale

1.2: 1 h / 10 °C

2.1: sodium hydroxide / methyl tributylammonium chloride / water; 2-methyltetrahydrofuran / 2.33 h / 20 °C / Industry scale

3.1: n-hexyllithium / hexane; 2-methyltetrahydrofuran / -20 - 10 °C / Industry scale

3.2: 19.33 h / 65 - 75 °C

4.1: sodium hydroxide; water / hexane; 2-methyltetrahydrofuran / 2 h / 60 °C / Industry scale

4.2: pH 3.5

5.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 0 °C

With dimethylsulfide borane complex; water; n-hexyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; methyl tributylammonium chloride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In 2-methyltetrahydrofuran; hexane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1029431-48-8
(R)-1-(4-bromophenyl)-2-chloroethanol

: 1240914-95-7
((1S,2S)-2-(4-bromophenyl)cyclopropyl)((R)-4-cyclobutyl-2-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methyl tributylammonium chloride / water; 2-methyltetrahydrofuran / 2.33 h / 20 °C / Industry scale

2.1: n-hexyllithium / hexane; 2-methyltetrahydrofuran / -20 - 10 °C / Industry scale

2.2: 19.33 h / 65 - 75 °C

3.1: sodium hydroxide; water / hexane; 2-methyltetrahydrofuran / 2 h / 60 °C / Industry scale

3.2: pH 3.5

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 15 h / 0 °C

With water; n-hexyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; methyl tributylammonium chloride; In 2-methyltetrahydrofuran; hexane; water; N,N-dimethyl-formamide;