Laureth-3 carboxylic acid

Base Information

• Chemical Name: Laureth-3 carboxylic acid
• CAS No.: 20858-24-6
• Molecular Formula: C₁₈H₃₆O₅
• Molecular Weight: 332.481
• UNII: NJW1UP36FA
• Wikidata: Q27284905
• Mol file: 20858-24-6.mol

Synonyms:Laureth-3 carboxylic acid;NJW1UP36FA;UNII-NJW1UP36FA;Acetic acid, (2-(2-(dodecyloxy)ethoxy)ethoxy)-;20858-24-6;EMPICOL CBB;SCHEMBL18140885;3,6,9-trioxa-heneicosanoic acid;LAURETH-3 CARBOXYLIC ACID [INCI];PEG-3 LAURYL ETHER CARBOXYLIC ACID;Q27284905;ACETIC ACID, 2-(2-(2-(DODECYLOXY)ETHOXY)ETHOXY)-

Chemical Property of Laureth-3 carboxylic acid

Chemical Property:

• PSA: 64.99000
• LogP: 4.04170
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 19
• Exact Mass: 332.25627424
• Heavy Atom Count: 23
• Complexity: 246

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCOCCOCCOCC(=O)O

Technology Process of Laureth-3 carboxylic acid

There total 3 articles about Laureth-3 carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

diethylene glycol monododecyl ether (3055-93-4,9015-55-8) + sodium monochloroacetic acid (3926-62-3) → [2-(2-Dodecyloxy-ethoxy)-ethoxy]-acetic acid (20858-24-6,27306-90-7)

Guidance literature:

With sodium; In xylene; at 110 - 130 ℃; for 16h;

Reference yield:

oxirane (75-21-8,99932-75-9) + 1-dodecyl alcohol (112-53-8) → 2-(dodecyloxy)acetic acid (6064-75-1) + (2-Dodecyloxy-ethoxy)-acetic acid (20858-23-5,27306-90-7) + [2-(2-Dodecyloxy-ethoxy)-ethoxy]-acetic acid (20858-24-6,27306-90-7)

Guidance literature:

oxirane; 1-dodecyl alcohol; With potassium hydroxide; at 155 ℃; for 2h; under 3000.3 Torr; Autoclave;

With oxygen; sodium hydroxide; In water; at 70 ℃; for 3.5h;

With hydrogenchloride; In water;

Reference yield:

2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol (3055-94-5,9015-55-8) → [2-(2-Dodecyloxy-ethoxy)-ethoxy]-acetic acid (20858-24-6,27306-90-7)

Guidance literature:

With Jones reagent; In acetone; at 20 ℃;

DOI:10.1002/rcm.4624

upstream raw materials:

diethylene glycol monododecyl ether

sodium monochloroacetic acid

2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol

oxirane