{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Base Information

Chemical Name:{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester
CAS No.:206196-70-5
Molecular Formula:C₂₄H₂₂ClN₃O₃S
Molecular Weight:467.976
Hs Code.:

Synonyms:{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Suppliers and Price of {2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of {2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

There total 3 articles about {2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 201230-82-2
carbon monoxide

: 21344-90-1
4-(o-chlorophenyl)-1,3-thiazol-2-amine

: 206196-82-9
(2-Iodo-indol-1-yl)-acetic acid tert-butyl ester

: 206196-70-5
{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; In N,N-dimethyl acetamide; at 112 - 113 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(98)00215-9

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 206196-70-5
{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfoxide

2: 33 percent / PdCl₂(PPh₃)2, Bu₃N / N,N-dimethyl-acetamide / 0.17 h / 112 - 113 °C

With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; In N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00215-9

Reference yield:

: sodium salt of 2-iodoindole

: 206196-70-5
{2-[4-(2-Chloro-phenyl)-thiazol-2-ylcarbamoyl]-indol-1-yl}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfoxide

2: 33 percent / PdCl₂(PPh₃)2, Bu₃N / N,N-dimethyl-acetamide / 0.17 h / 112 - 113 °C

With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; In N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00215-9