9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Base Information

Chemical Name:9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine
CAS No.:306305-04-4
Molecular Formula:C₃₄H₄₁N₅O₅Si
Molecular Weight:627.816
Hs Code.:

Synonyms:9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Suppliers and Price of 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

There total 1 articles about 9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 233266-82-5
1,2-di-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-D-ribo-pentofuranose

: 306305-04-4
9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; for 25.5h; Heating;
DOI:10.1021/jm000209n

Reference yield: 86.0%

: 306305-04-4
9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

: 306305-05-5
9-(3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

Guidance literature:: With methanol; triethylamine; at 20 ℃; for 24h;
DOI:10.1021/jm000209n

Reference yield:

: 306305-04-4
9-(2-O-acetyl-3,5-di-O-benzyl-4-C-triethylsilylethynyl-β-D-ribo-pentofuranosyl)adenine

: 1054625-37-4
9-((2R,4S,5R)-4-Benzyloxy-5-benzyloxymethyl-5-ethynyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / triethylamine; methanol / 24 h / 20 °C

2: 4-(dimethylamino)pyridine / acetonitrile / 1 h / 20 °C

3: 2,2'-azobis(isobutyronitrile); tri-n-butyltin hydride / toluene / 1 h / 85 °C

4: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

With methanol; dmap; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; triethylamine; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1021/jm000209n