(3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

Base Information

Chemical Name:(3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol
CAS No.:616890-47-2
Molecular Formula:C₂₈H₄₅NO₅Si
Molecular Weight:503.755
Hs Code.:

Synonyms:(3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

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Chemical Property of (3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

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Technology Process of (3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

There total 4 articles about (3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 616890-46-1
(3S,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hex-1-ene

: 616890-47-2
(3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

Guidance literature:: With osmium(VIII) oxide; trimethylamine-N-oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 5h;
DOI:10.1021/jm0302086

Reference yield:

: (2R)-4-(tert-butyldimethylsilyloxy)-2-(dibenzylamino)butanal

: 616890-47-2
(3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 4.87 g / tetrahydrofuran / -78 - 20 °C

2: 83 percent / ethyldiisopropylamine; KI / 1,2-dimethoxy-ethane / 3 h / Heating

3: 81 percent / trimethylamine oxide dihydrate; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 5 h / 20 °C

With osmium(VIII) oxide; trimethylamine-N-oxide; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; water; tert-butyl alcohol;
DOI:10.1021/jm0302086

Reference yield:

: 616890-44-9
(2R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

: 616890-47-2
(3R,4R)-4-(dibenzylamino)-6-(tert-butyldimethylsilyloxy)-3-(methoxymethoxy)hexane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2: 4.87 g / tetrahydrofuran / -78 - 20 °C

3: 83 percent / ethyldiisopropylamine; KI / 1,2-dimethoxy-ethane / 3 h / Heating

4: 81 percent / trimethylamine oxide dihydrate; OsO₄ / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 5 h / 20 °C

With osmium(VIII) oxide; oxalyl dichloride; trimethylamine-N-oxide; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; tert-butyl alcohol; 1: Swern oxidation;
DOI:10.1021/jm0302086