N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine

Base Information

• Chemical Name: N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine
• CAS No.: 1269662-90-9
• Molecular Formula: C₁₆H₁₄ClFN₄O
• Molecular Weight: 332.765
• Mol file: 1269662-90-9.mol

Synonyms:N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine

Chemical Property of N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine

There total 19 articles about N⁴-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-(3-chloro-4-fluorophenyl)-7-ethoxy-6-nitroquinazoline-4-amine (1360430-70-1) → N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine (1269662-90-9)

Guidance literature:

With iron; acetic acid; In ethanol; water; for 2h; Reflux;

DOI:10.1021/jm201507x

Reference yield: 73.0%

6-acetamido-4-(3-chloro-4-fluoroaniline)-7-ethoxyquinazoline → N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine (1269662-90-9)

Guidance literature:

With potassium hydroxide; In propan-1-ol; water; for 2h; Reflux;

DOI:10.1016/j.ejmech.2018.11.029

Reference yield:

7-Chloro-6-nitro-quinazolin-4-one (53449-14-2) → N4-(3-chloro-4-fluorophenyl)-7-ethoxyquinazoline-4,6-diamine (1269662-90-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium / 72 h / Reflux

2: trichlorophosphate / 0.5 h / Reflux

3: hydrogenchloride / water; isopropyl alcohol / Reflux

4: iron; acetic acid / ethanol; water / 2 h / Reflux

With hydrogenchloride; sodium; iron; acetic acid; trichlorophosphate; In ethanol; water; isopropyl alcohol;

DOI:10.1021/jm201507x

upstream raw materials:

4-chloro-7-ethoxy-6-nitroquinazoline

7-chloroquinazolin-4(1H)-one

7-Chloro-6-nitro-quinazolin-4-one

7-ethoxy-6-nitroquinazolin-4(1H)-one

Downstream raw materials:

N-(4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)-3-(dimethylamino)propanamide

N-(4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)-3-piperidin-1-ylpropanamide

N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-morpholinopropanamide

N-(4-(3-chloro-4-fluoroanilino)-7-ethoxyquinazolin-6-yl)acrylamide