(S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate

Base Information

• Chemical Name: (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate
• CAS No.: 1442649-63-9
• Molecular Formula: C₂₁H₂₀O₃S
• Molecular Weight: 352.454
• Mol file: 1442649-63-9.mol

Synonyms:(S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate

Chemical Property of (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate

There total 3 articles about (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(S)-(4-methoxyphenyl)(naphthalen-2-yl)methanol + methylsulfanyl-acetic acid (2444-37-3) → (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate (1442649-63-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja4034999

Reference yield:

β-naphthaldehyde (66-99-9) → (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate (1442649-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethylzinc / toluene / 24 h / 65 °C / Inert atmosphere

1.2: 0.17 h / 0 °C / Inert atmosphere

1.3: 24 h / 0 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; diethylzinc; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1021/ja4034999

Reference yield:

4-methoxyphenylboronic acid (5720-07-0) → (S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate (1442649-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diethylzinc / toluene / 24 h / 65 °C / Inert atmosphere

1.2: 0.17 h / 0 °C / Inert atmosphere

1.3: 24 h / 0 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C / Inert atmosphere

With dmap; diethylzinc; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1021/ja4034999

upstream raw materials:

β-naphthaldehyde

4-methoxyphenylboronic acid

methylsulfanyl-acetic acid

Downstream raw materials:

(R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene