2444-37-3

Basic information

• Product Name: (METHYLTHIO)ACETIC ACID
• Synonyms: 2-(METHYLTHIO)ACETIC ACID;(METHYLMERCAPTO)ACETIC ACID;(METHYLTHIO)ACETIC ACID;RARECHEM AL BO 0139;(Methylsulfanyl)acetic acid;Acetic acid, (methylthio)-;(Methylthio)aceticacid,98%;2-(Methylthio)acetic acid 99%
• CAS NO: 2444-37-3
• Molecular Formula: C₃H₆O₂S
• Molecular Weight: 106.14
• EINECS: 219-483-6
• Product Categories: Aliphatics;Carboxylic Acids;Carboxylic Acids;Building Blocks;C1 to C5;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 2444-37-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 13-14 °C(lit.)
• Boiling Point: 130-131 °C27 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.219 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0307mmHg at 25°C
• Refractive Index: n20/D 1.495(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.66(at 25℃)
• Sensitive: Stench
• BRN: 1740201
• CAS DataBase Reference: (METHYLTHIO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (METHYLTHIO)ACETIC ACID(2444-37-3)
• EPA Substance Registry System: (METHYLTHIO)ACETIC ACID(2444-37-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3334
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2444-37-3(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to pale yellow liquid

Uses

(Methylthio)acetic acid may be used in the synthesis of (5S,6S,8S)-8-acetoxy-6-(3,4-methylenedioxyphenyl)-1-[(methylthio)-acetyl]-1-azaspiro[4.4]nonane.

General Description

Formation of complexes of methyl thioacetate and copper(II) has been investigated. (Methylthio)acetic acid is an irreversible inhibitor of sarcosine oxidase and is effective in preventing the complete enzyme inactivation during modification.

InChI:InChI=1/C3H6O2S/c1-6-2-3(4)5/h2H2,1H3,(H,4,5)

Upstream product

• 562-54-9 potassium methyl sulfate 
• 68-11-1 mercaptoacetic acid 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 105-39-5 chloroacetic acid ethyl ester 
• 5188-07-8 sodium thiomethoxide 
• 4727-41-7 dimethylsulfonioacetate 
• 108-95-2 phenol 
• 2068-24-8 methylenedithiodiacetic acid 
• 7647-01-0 hydrogenchloride 
• 24310-22-3 2-(tert-butylthio)acetic acid 
• 7732-18-5 water 
• 35120-10-6 methylthioacetonitrile 
• 4455-13-4 methylthioacetic acid ethyl ester 

Downstream Products

• 298-12-4 Glyoxilic acid 
• 108263-47-4 2-chloro-10-(4-(2-methylthioacetoxyethyl)piperazino)-10,11-dihydrodibenzothiepin 
• 161364-48-3 2-<(2-hydroxyphenoxy)methyl>-3-<2-(methylthio)acetyl>-1,3-thiazolidine 
• 161364-47-2 2-<(2-methoxyphenoxy)methyl>-3-<2-(methylthio)acetyl>-1,3-thiazolidine 
• 221021-09-6 methylsulfanyl-acetic acid p-tolyl ester 
• 4727-41-7 dimethylsulfonioacetate 
• 58992-38-4 (C₆H₅)3Bi(OOCCH₂SCH₃)2 
• 7647-01-0 hydrogenchloride 
• 104923-33-3 mercury(I) chloride 
• 53356-94-8 methanethiol; mercury (II)-compound 
• 932704-02-4 [(N,N-bis((6-phenyl-2-pyridyl)methyl)-N-((2-pyridyl)methyl)amine)Ni(H₂O)(methylthioacetato)]ClO₄ 
• 932703-92-9 [(N,N-bis((6-phenyl-2-pyridyl)methyl)-N-((2-pyridyl)methyl)amine)Ni(methylthioacetato)]ClO₄ 
• 1429403-38-2 2-methylsulfanyl-N-(5-phenylethynyl-pyridin-2-yl)-acetamide 

Relevant articles and documents

HETEROCYCLIC AMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a heterocyclic amide compound useful as an active ingredient of a herbicide. SOLUTION: The present disclosure provides a heterocyclic amide compound represented by the following formula or a salt thereof. Q-N(R3)-C(=X)-W (Q: a substituted/unsubstituted 1,3,4-oxadiazole, 1,2,5-oxadiazole or the like. W: a substituted/unsubstituted [1,2,4]triazolo[4,3-a]pyridine or the like. X: O, S. R3: H, C1-C6 alkyl or the like). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Development of 11C-Labeled ω-sulfhydryl fatty acid tracer for myocardial imaging with PET

[11C]-S-methyl-16-thiopalmitic acid (a) was developed with excellent heart-to-background uptake ratios and higher retention in heart. Myocardial uptake and metabolism of the tracer is markedly higher CPT I dependent. When compared to [11C]-S-methyl-14-thiomyristic acid (b), [11C]-S-methyl-12-thiododecanoic acid (c) and [11C]-palmitate, a showed an early high uptake and a significantly slower late clearance in heart and a prolonged myocardial elimination half-life (30 min). Analysis of heart tissue and urine samples showed that a was metabolized via beta-oxidation in myocardium. Small animal PET images of the accumulation of a in the rat myocardium were clearly superior to [11C]-palmitate. These initial studies suggest that a could be a potentially useful clinical PET tracer to assess myocardial fatty acid metabolism.

HETEROCYCLIC AMIDO COMPOUND

PROBLEM TO BE SOLVED: To provide a novel pesticide, especially a herbicide. SOLUTION: There are provided a heterocycle amide compound such as 3-isopropyl-N-(5-methyl-1, 3, 4-oxadiazole-2-yl)-5-(trifluoromethyl)-[1, 2, 4]triazolo [4,3-a] pyridine-8-carboxamide (compound No.1-004), 3-isopropyl-N-(5-methyl-1, 3, 4-oxadiazole-2-yl)-5-(methylthio)-[1,2,4] triazolo [4,3-a] pyridine-8-carboxamide (compound No.1-009), and a herbicide containing them. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT