(R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene

Base Information

• Chemical Name: (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene
• CAS No.: 1442898-25-0
• Molecular Formula: C₁₉H₁₈O
• Molecular Weight: 262.351
• Mol file: 1442898-25-0.mol

Synonyms:(R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene

Chemical Property of (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene

There total 12 articles about (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate (1442649-63-9) + dimethyl zinc(II) (544-97-8) → (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene (1442898-25-0)

Guidance literature:

With [nickel(II)dichloride(dimethoxyethane)]; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 0 ℃; for 48h; enantiospecific reaction; Inert atmosphere;

DOI:10.1021/ja4034999

Reference yield: 40.0%

2-naphthylethylene (827-54-3,28406-56-6) + 4-methoxyphenyl triflate (66107-29-7) → (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene (1442898-25-0) + 2-(4-methoxyphenethyl)naphthalene

Guidance literature:

With potassium phosphate monohydrate; (1,2-dimethoxyethane)dichloronickel(II); C₂₄H₂₄N₂O; In methanol; diethyl ether; toluene; at 0 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1055/a-1523-3228

Reference yield: 12.0%

O-(1-(naphthalen-2-yl)ethyl) benzoyl(phenyl)carbamothioate + 4-methoxyphenylzinc(II) methoxide → (S)-2-(1-(4-methoxyphenyl)ethyl)naphthalene (1424035-17-5) + (R)-2-(1-(4-methoxyphenyl)ethyl)naphthalene (1442898-25-0) + O-(1-(naphthalen-2-yl)ethyl) 4-methoxybenzothioate

Guidance literature:

O-(1-(naphthalen-2-yl)ethyl) benzoyl(phenyl)carbamothioate; With nickel(II) acetylacetonate monohydrate; Bathocuproine; magnesium chloride; In 1,4-dioxane; at 23 ℃; for 0.0833333h; Inert atmosphere; Sealed tube;

4-methoxyphenylzinc(II) methoxide; In tetrahydrofuran; 1,4-dioxane; at 23 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.0c06904

upstream raw materials:

(S)-(4-methoxyphenyl)(naphthalen-2-yl)methyl 2-(methylthio)acetate

dimethyl zinc(II)

β-naphthaldehyde

4-methoxyphenylboronic acid