ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Base Information

Chemical Name:ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate
CAS No.:1179986-68-5
Molecular Formula:C₂₄H₁₅F₄NO₉S
Molecular Weight:569.444
Hs Code.:

Synonyms:ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

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Chemical Property of ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

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Technology Process of ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

There total 7 articles about ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1179986-67-4
ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1179986-68-5
ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1179986-66-3
ethyl 2-(4-(4-fluorophenoxy)phenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1179986-68-5
ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trichloride / dichloromethane / 0.33 h / Cooling with ice; Inert atmosphere

1.2: Cooling with ice

2.1: dmap; triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With dmap; boron trichloride; triethylamine; In dichloromethane;

Reference yield:

: 99-90-1
para-bromoacetophenone

: 1179986-68-5
ethyl 2-(4-(4-fluorophenoxy)phenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)benzofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / toluene; mineral oil / 2 h / 0 - 20 °C

1.2: Reflux

2.1: zinc(II) chloride / N,N-dimethyl-formamide / 3.5 h / 105 °C

3.1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.33 h / 20 °C

3.2: 4 h / 80 °C

4.1: nitric acid / dichloromethane / 1.5 h / 0 - 20 °C

5.1: potassium phosphate / palladium diacetate; tert-butyl XPhos / toluene / 2 h / 100 °C / Inert atmosphere

6.1: boron trichloride / dichloromethane / -78 - -40 °C

7.1: triethylamine / dmap / dichloromethane / 1 h / 0 - 20 °C

With potassium phosphate; nitric acid; boron trichloride; sodium hydride; caesium carbonate; triethylamine; zinc(II) chloride; dmap; palladium diacetate; tert-butyl XPhos; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;