5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone

Base Information

• Chemical Name: 5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone
• CAS No.: 124337-87-7
• Molecular Formula: C₂₇H₃₁NO₃S
• Molecular Weight: 449.614
• Mol file: 124337-87-7.mol

Synonyms:5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone

Chemical Property of 5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone

There total 2 articles about 5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Δ1.6-1-triemthylsilyloxy-3-methyl-3-vinylcyclohexene (124337-86-6) + α,α-dimethyl-1-(p-toluenesulfonyl)-1H-indole-4-methanol (124337-85-5) → 5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone (124337-87-7)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -78 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.09.086

Reference yield:

chloro-trimethyl-silane (75-77-4) + 3-methyl-3-vinylcyclohexan-1-one (68269-56-7,54735-44-3) + α,α-dimethyl-1-(p-toluenesulfonyl)-1H-indole-4-methanol (124337-85-5) → 3-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-3-vinyl-cyclohexanone (124337-88-8) + 5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone (124337-87-7)

Guidance literature:

With tin(IV) chloride; lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, -73 deg C, 5 min, 2) CH₂Cl₂, -78 deg C, 10 min;

DOI:10.1016/S0040-4020(01)96005-3

Reference yield: 80.0%

5-Methyl-2-{1-methyl-1-[1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethyl}-5-vinyl-cyclohexanone (124337-87-7) → 2,6,7,8,9,10-hexahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1.2.3-cd>indole (124337-89-9)

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.09.086

upstream raw materials:

chloro-trimethyl-silane

3-methyl-3-vinylcyclohexan-1-one

α,α-dimethyl-1-(p-toluenesulfonyl)-1H-indole-4-methanol

Δ^1.6-1-triemthylsilyloxy-3-methyl-3-vinylcyclohexene

Downstream raw materials:

2,6,7,8,9,10-hexahydro-6,6,9-trimethyl-2-p-toluenesulfonyl-9-vinylnaphth<1.2.3-cd>indole