1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Base Information

Chemical Name:1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester
CAS No.:467443-31-8
Molecular Formula:C₂₄H₂₂Cl₂N₂O₅
Molecular Weight:489.355
Hs Code.:

Synonyms:1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

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Chemical Property of 1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

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Technology Process of 1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

There total 8 articles about 1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 79-37-8
oxalyl dichloride

: 467443-23-8
1-[3-(3,4-dichloro-benzyl)-ureido]-cyclohexanecarboxylic acid benzyl ester

: 467443-31-8
1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.3797/scipharm.aut-01-204

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 467443-31-8
1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: sodium azide / toluene / 1 h / Heating

3: 74 percent / CHCl₃ / 3 h / 20 °C

4: 67 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; In tetrahydrofuran; chloroform; toluene;
DOI:10.3797/scipharm.aut-01-204

Reference yield:

: 1805-32-9
3,4-dichlorobenzyl alcohol

: 467443-31-8
1-[3-(3,4-dichloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: PBr₃ / CH₂Cl₂

2: AcOH; H₂SO₄

3: thionyl chloride

4: sodium azide / toluene / 1 h / Heating

5: 74 percent / CHCl₃ / 3 h / 20 °C

6: 67 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; sulfuric acid; phosphorus tribromide; acetic acid; In tetrahydrofuran; dichloromethane; chloroform; toluene;
DOI:10.3797/scipharm.aut-01-204