3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone

Base Information

• Chemical Name: 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone
• CAS No.: 141353-92-6
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.281
• Mol file: 141353-92-6.mol

Synonyms:3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone

Chemical Property of 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone

Chemical Property:

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Technology Process of 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone

There total 1 articles about 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-methylacetoacetamide (20306-75-6) + benzaldehyde (100-52-7) + urea (57-13-6) → 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone (141353-92-6)

Guidance literature:

With hydrogenchloride; In ethanol; Ambient temperature;

DOI:10.1016/0223-5234(92)90066-A

Reference yield: 35.0%

benzaldehyde (100-52-7) + 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone (141353-92-6) → (E)-N-methyl-2-oxo-4-phenyl-6-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide (1565871-12-6)

Guidance literature:

benzaldehyde; 3,4-dihydro-6-methyl-5-N-methylcarbamoyl-4-phenyl-2(1H)-pyrimidinone; With iron(III) chloride hexahydrate; In acetonitrile; for 8h; Reflux;

DOI:10.1021/jo402773r

upstream raw materials:

N-methylacetoacetamide

benzaldehyde

urea

Downstream raw materials:

(E)-N-methyl-2-oxo-4-phenyl-6-styryl-1,2,3,4-tetrahydropyrimidine-5-carboxamide