rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

Base Information

Chemical Name:rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile
CAS No.:1234620-65-5
Molecular Formula:C₁₅H₁₅N₇O₃S
Molecular Weight:373.395
Hs Code.:

Synonyms:rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

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Chemical Property of rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

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Technology Process of rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

There total 6 articles about rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455-77-2
guanazole

: 1234620-63-3
4-(2-cyano-3-oxobut-1-en-1-yl)-3-(methylsulfonyl)benzonitrile

: 1234620-65-5
rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

Guidance literature:: With pyridine; rac-Pro-OH; In N,N-dimethyl-formamide; for 192h; Inert atmosphere; Molecular sieve;

Reference yield:

: 1161921-91-0
4-methyl-3-(methylsulfonyl)benzonitrile

: 1234620-65-5
rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

2: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

3: piperidine; acetic acid / dichloromethane / 18 h / Reflux

4: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

With piperidine; pyridine; sodium periodate; acetic acid; rac-Pro-OH; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 170572-49-3
2-fluoro-4-cyanotoluene

: 1234620-65-5
rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide / 20 °C / Heating

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 10 - 20 °C

3: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

4: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

5: piperidine; acetic acid / dichloromethane / 18 h / Reflux

6: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

With piperidine; pyridine; sodium periodate; acetic acid; 3-chloro-benzenecarboperoxoic acid; rac-Pro-OH; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;