(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Base Information

Chemical Name:(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile
CAS No.:1234620-66-6
Molecular Formula:C₂₃H₁₅N₇O₄S
Molecular Weight:485.483
Hs Code.:

(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Synonyms:(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Chemical Property of (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

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Technology Process of (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

There total 8 articles about (rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 85-44-9
phthalic anhydride

: 1234620-64-4
(rac)-2-amino-7-[4-cyano-2-(methylsulfonyl)phenyl]-5-methyl-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

: 1234620-66-6
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: With pyridine; triethylamine; In toluene; for 2h; Inert atmosphere; Reflux;
DOI:10.1002/cmdc.201500269

Reference yield:

: 1234620-63-3
4-(2-cyano-3-oxobut-1-en-1-yl)-3-(methylsulfonyl)benzonitrile

: 1234620-66-6
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; rac-Pro-OH / N,N-dimethyl-formamide / 192 h / Inert atmosphere; Molecular sieve

2: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

3: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

With pyridine; toluene-4-sulfonic acid; triethylamine; rac-Pro-OH; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 1234620-65-5
rac-4-[2-cyano-1-(3,5-diamino-1H-1,2,4-triazol-1-yl)-3-oxobutyl]-3-(methylsulfonyl)benzonitrile

: 1234620-66-6
(rac)-7-[4-cyano-2-(methylsulfonyl)phenyl]-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-methyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; pyridine / toluene / 1 h / Reflux

2: triethylamine; pyridine / toluene / 2 h / Inert atmosphere; Reflux

With pyridine; toluene-4-sulfonic acid; triethylamine; In toluene;