(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

Base Information

Chemical Name:(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester
CAS No.:1026380-94-8
Molecular Formula:C₃₃H₃₈N₆O₅
Molecular Weight:598.702
Hs Code.:

(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

Synonyms:(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

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Chemical Property of (3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

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Technology Process of (3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

There total 8 articles about (3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 528882-16-8
(3-amino-phenyl)-methyl-carbamic acid tert-butyl ester

: 528882-21-5
(1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-5-(pyridin-2-yl)-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetic acid

: 1026380-94-8
(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm051219x

Reference yield:

: 42471-56-7
2-(2-aminobenzoyl)pyridine

: 1026380-94-8
(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / ethanol / 16 h / Heating

2.1: 100 percent / NEt₃ / CH₂Cl₂ / 1 h / 20 °C

3.1: NaH / dimethylformamide / 0.5 h / 20 °C

3.2: 63 percent / dimethylformamide / 2 h / 20 °C

4.1: 100 percent / aq. NaOH / ethanol / 16 h / 20 °C

5.1: 75 percent / 1-hydroxybenzotriazole; 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With dmap; sodium hydroxide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm051219x

Reference yield:

: 528882-15-7
N-methyl-(3-nitrophenyl)carbamic acid tert-butyl ester

: 1026380-94-8
(3-(2-(5-pyridin-2-yl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetylamino)phenyl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Pd/C / methanol; tetrahydrofuran

2: 75 percent / 1-hydroxybenzotriazole; 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm051219x