(5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

Base Information

Chemical Name:(5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid
CAS No.:1408448-99-6
Molecular Formula:C₂₈H₄₃NO₉
Molecular Weight:537.651
Hs Code.:

Synonyms:(5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

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Chemical Property of (5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

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Technology Process of (5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

There total 6 articles about (5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1408448-97-4
4-benzyl 1,4-di-tert-butyl (1S)-6-[4-(benzyloxy)phenyl]-1-[(tert-butoxycarbonyl)amino]hexane-1,4,4-tricarboxylate

: 1408448-99-6
(5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 16h;

Reference yield:

: 81323-58-2
N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

: 1408448-99-6
(5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 60 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

With N-Bromosuccinimide; hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 61439-59-6
2-(4-benzyloxyphenyl)ethanol

: 1408448-99-6
(5S)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-2-[2-(4-hydroxyphenyl)ethyl]-6-oxohexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 3 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C

With carbon tetrabromide; hydrogen; sodium hydride; triphenylphosphine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;