4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Base Information

Chemical Name:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide
CAS No.:254744-58-6
Molecular Formula:C₃₄H₄₂N₄O₇S
Molecular Weight:650.796
Hs Code.:

Synonyms:4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

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Chemical Property of 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

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Technology Process of 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

There total 7 articles about 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 176961-13-0
2-borono-N-(3,4-dimethyl-5-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide

: 254744-56-4
4-[(2-n-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-formylbromobenzene

: 254744-58-6
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; for 2h; Heating;
DOI:10.1021/jm020138n

Reference yield: 60.0%

: 254744-58-6
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:

Reference yield:

: 160313-50-8
2-[(2'-bromo-5'-cyano)phenyl]-1,3-dioxolane

: 254744-58-6
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2'-formyl-N-(3,4-dimethyl-5-isoxazolyl)-N-([(2-methoxy)ethoxy]methyl)[1,1'-biphenyl]-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 70.5 g / DIBAL-H / toluene / 17 h / -78 - 20 °C

2.1: sodium borohydride / ethanol / 2 h / 0 °C

3.1: 31.1 g / carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 2 h / 0 °C

4.1: sodium hydride / dimethylformamide / 0.25 h / 0 - 20 °C

4.2: 42.7 g / dimethylformamide / 14 h

5.1: 8.2 g / 1 N HCl / tetrahydrofuran / 1 h / 65 °C

6.1: 77 percent / (Ph₃P)4Pd; aq. sodium carbonate / toluene; aq. ethanol / 2 h / Heating

With hydrogenchloride; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; diisobutylaluminium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 6.1: Suzuki coupling;
DOI:10.1021/jm020138n