methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride

Base Information

• Chemical Name: methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride
• CAS No.: 206438-31-5
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Mol file: 206438-31-5.mol

Synonyms:methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride

Chemical Property of methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

(S)-Methyl 2-amino-3-cyclopropylpropanoate HCl 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (S)?-?Methyl 2-?Amino-?3-?cyclopropylpropanoat?e Hydrochloride is a reactant used in the preparation of broad-spectrum inhibitors of coronavirus and enterovirus replication.

Technology Process of methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride

There total 3 articles about methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (2S)-2-amino-3-cyclopropylpropanoic acid (102735-53-5,15785-52-1) → methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride (206438-31-5)

Guidance literature:

With sulfuric acid; Reflux;

DOI:10.1016/j.bmcl.2018.03.020

Reference yield: 59.0%

methanol (67-56-1) + (2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid (89483-06-7,89483-08-9) → methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride (206438-31-5)

Guidance literature:

With thionyl chloride; at 20 ℃; for 24h;

Reference yield:

→ methyl (S)-2-amino-3-cyclopropylpropanoate hydrochloride (206438-31-5)

Guidance literature:

upstream raw materials:

methanol

(2S)-2-[[(tert-butoxy)carbonyl]amino]-3-cyclopropylpropanoic acid

(2S)-2-amino-3-cyclopropylpropanoic acid