dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

Base Information

Chemical Name:dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate
CAS No.:1548658-78-1
Molecular Formula:C₁₇H₂₆O₅Si
Molecular Weight:338.476
Hs Code.:

Synonyms:dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

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Chemical Property of dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

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Technology Process of dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

There total 32 articles about dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (1E)-3-(tert-butyldimethylsilyloxy)-1-dimethylamino-1,3-pentadiene

: 100-52-7
benzaldehyde

: 762-42-5
dimethyl acetylenedicarboxylate

: 1548658-78-1
dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

: 83399-62-6,83399-63-7,111900-67-5,111900-68-6
(2S,3S)-3-methyl-2-phenyl-2,3-dihydro-4H-pyran-4-one

Guidance literature:: (1E)-3-(tert-butyldimethylsilyloxy)-1-dimethylamino-1,3-pentadiene; benzaldehyde; With C₆₈H₅₂N₈O₁₂Rh₂*3H₂O; In dichloromethane; at -20 ℃; for 8h; Inert atmosphere;

dimethyl acetylenedicarboxylate; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With acetyl chloride; In dichloromethane; at -78 ℃; for 0.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.10.016

Reference yield: 97.0%

: 104-53-0
3-phenyl-propionaldehyde

: (1E)-3-(tert-butyldimethylsilyloxy)-1-dimethylamino-1,3-pentadiene

: 762-42-5
dimethyl acetylenedicarboxylate

: (2R*,3S*)-3-methyl-2-(2-phenylethyl)-2,3-dihydro-4H-pyran-4-one

: 1548658-78-1
dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

Guidance literature:: 3-phenyl-propionaldehyde; (1E)-3-(tert-butyldimethylsilyloxy)-1-dimethylamino-1,3-pentadiene; With C₆₈H₅₂N₈O₁₂Rh₂*3H₂O; In dichloromethane; at -20 ℃; for 6h; Inert atmosphere;

dimethyl acetylenedicarboxylate; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With acetyl chloride; In dichloromethane; at -78 ℃; for 0.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.10.016

Reference yield: 95.0%

: (1E)-3-(tert-butyldimethylsilyloxy)-1-dimethylamino-1,3-pentadiene

: 66-25-1
hexanal

: 762-42-5
dimethyl acetylenedicarboxylate

: 1548658-91-8
(2R,3S)-3-methyl-2-pentyl-2,3-dihydro-4H-pyran-4-one

: 1548658-78-1
dimethyl 4-(tert-butyldimethylsilyloxy)-3-methylbenzene-1,2-dicarboxylate

Guidance literature:: (1E)-3-(tert-butyldimethylsilyloxy)-1-dimethylamino-1,3-pentadiene; hexanal; With C₆₈H₅₂N₈O₁₂Rh₂*3H₂O; In dichloromethane; at -20 ℃; for 6h; Inert atmosphere;

dimethyl acetylenedicarboxylate; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

With acetyl chloride; In dichloromethane; at -78 ℃; for 0.5h; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.10.016