2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide

Base Information

• Chemical Name: 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide
• CAS No.: 229004-26-6
• Molecular Formula: C₃₁H₃₄N₂O
• Molecular Weight: 450.624
• Mol file: 229004-26-6.mol

Synonyms:2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide

Chemical Property of 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide

There total 21 articles about 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(4-aminobenzyl)piperidine (29608-05-7) + 3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl chloride → 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide (229004-26-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm9906264

Reference yield: 86.0%

1-(4-aminobenzyl)piperidine dihydrochloride (916739-30-5) + 2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid (229006-88-6) → 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide (229004-26-6)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile; at 20 ℃;

DOI:10.1039/c4ob02397h

Reference yield:

oxalyl dichloride (79-37-8) + 1-(4-aminobenzyl)piperidine (29608-05-7) + 2-(4-methylphenyl)-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid (229006-88-6) → 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide (229004-26-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N-methyl-acetamide; dichloromethane; water;

upstream raw materials:

1-(4-aminobenzyl)piperidine

piperidine

ethyl glutaroyl chloride

bromobenzene