N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide

Base Information

• Chemical Name: N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide
• CAS No.: 1179329-84-0
• Molecular Formula: C₁₉H₁₇F₅N₄O₄S
• Molecular Weight: 492.426
• Mol file: 1179329-84-0.mol

Synonyms:N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide

Chemical Property of N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide

There total 8 articles about N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}N'-tert-butyloxycarbonylsulfamide (1179329-83-9) → N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide (1179329-84-0)

Guidance literature:

With water; trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

1-(bromomethyl)-4-fluoro-2-nitrobenzene (76437-44-0) → N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide (1179329-84-0)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile

2: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 20 °C

4: trifluoroacetic acid; water / dichloromethane / 20 °C

With H₃B*NMe₃; water; caesium carbonate; triethylamine; trifluoroacetic acid; 20 % Pd(OH)2/C; In methanol; dichloromethane; acetonitrile;

Reference yield:

1-fluoro-4-isocyanato-2-(trifluoromethyl)benzene → N-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}sulfamide (1179329-84-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 1 h / 70 °C

1.2: 2 h / 70 °C

2.1: caesium carbonate / acetonitrile

3.1: H3B*NMe3 / 20 % Pd(OH)2/C / methanol / 4 h / Reflux; Inert atmosphere

4.1: triethylamine / dichloromethane / 20 °C

5.1: trifluoroacetic acid; water / dichloromethane / 20 °C

With H₃B*NMe₃; water; caesium carbonate; triethylamine; trifluoroacetic acid; 20 % Pd(OH)2/C; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

upstream raw materials:

(4-fluoro-3-nitrophenyl)methanol

1-(bromomethyl)-4-fluoro-2-nitrobenzene

5,5-dimethyl-3-(α,α,α,4-tetrafluoro-m-tolyl)hydantoin

1-(2-amino-4-fluorobenzyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-5,5-dimethylimidazolidine-2,4-dione

Downstream raw materials:

1-{5-fluoro-2-[3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}-3-(4-methanesulfonylphenyl)sulfamide

Refernces

• 1、 -. "Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof". . . Retrieved 2011/08/04.