2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide

Base Information

• Chemical Name: 2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide
• CAS No.: 78823-09-3
• Molecular Formula: C₂₇H₂₂ClN₃O₅
• Molecular Weight: 503.942
• Mol file: 78823-09-3.mol

Synonyms:2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide

Chemical Property of 2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide

There total 1 articles about 2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(methylamino-acetamido)-5-chloro-benzophenone (57180-64-0) + 2-phthalimidopropionic acid (21860-84-4) → 2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide (78823-09-3)

Guidance literature:

With thionyl chloride; Yield given. Multistep reaction; 1) HMPA, MeCN, 15 min, 2) ether, -5 deg C - 0 deg C, 2 h;

DOI:10.1021/jo00335a034

Reference yield: 29.0%

2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide (78823-09-3) → 5-chloro-2-aminobenzophenone (719-59-5) + 2'-Benzoyl-4'-chloro-N-(DL-alanyl)sarcosinanilide (78823-10-6)

Guidance literature:

With hydrazine hydrate; In ethanol; chloroform; for 15h; Ambient temperature;

DOI:10.1021/jo00335a034

Reference yield:

2'-Benzoyl-4'-chloro-N-(N-phthaloyl-DL-alanyl)sarcosinanilide (78823-09-3) → 5-chloro-2-(methylamino)benzophenone (1022-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) THF, 0 to -8 deg C, 30 min, 2) 0 - -8 deg C to RT, then 1.5 h

2: 2.1 percent / N₂H₄*H₂O / CHCl₃; ethanol / Ambient temperature

With sodium hydride; hydrazine hydrate; In ethanol; chloroform;

DOI:10.1021/jo00335a034

upstream raw materials:

2-(methylamino-acetamido)-5-chloro-benzophenone

2-phthalimidopropionic acid

Downstream raw materials:

5-chloro-2-aminobenzophenone

2'-Benzoyl-4'-chloro-N-(DL-alanyl)sarcosinanilide

N-(N-phthaloyl-DL-alanyl)-N'-methyl-2'-benzoyl-4'-chlorosarcosinanilide

8-Chloro-10-phenyl-1,3,5-trimethyl-1H-pyrazino<2,3-b>quinolin-2(3H)-one