N-(p-methoxybenzyl)-2-acetamide

Base Information

• Chemical Name: N-(p-methoxybenzyl)-2-acetamide
• CAS No.: 117471-51-9
• Molecular Formula: C₂₀H₂₂Cl₂N₂O₄
• Molecular Weight: 425.312

Synonyms:N-(p-methoxybenzyl)-2-acetamide

Chemical Property of N-(p-methoxybenzyl)-2-acetamide

Chemical Property:

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Technology Process of N-(p-methoxybenzyl)-2-acetamide

There total 1 articles about N-(p-methoxybenzyl)-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

dichloroacethyl chloride (79-36-7) + N,N'-bis(p-methoxybenzyl)-α-aminoacetamide (117471-50-8) → N-(p-methoxybenzyl)-2-acetamide (117471-51-9)

Guidance literature:

With potassium carbonate; In dichloromethane;

DOI:10.1021/jo00259a036

Reference yield: 88.0%

homoalylic alcohol (627-27-0) + N-(p-methoxybenzyl)-2-acetamide (117471-51-9) → 1,4-bis(4-methoxybenzyl)-3-(but-3-en-1-yloxy)piperazine-2,5-dione (117471-62-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1002/anie.201504883

Reference yield: 83.0%

1,4-butenediol (6117-80-2) + N-(p-methoxybenzyl)-2-acetamide (117471-51-9) → (Z)-1,4-bis(p-methoxybenzyl)-3-(4'-hydroxy-2'-butenoxy)-2,5-piperazinedione (117471-53-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 2h; Heating;

upstream raw materials:

dichloroacethyl chloride

N,N'-bis(p-methoxybenzyl)-α-aminoacetamide

Downstream raw materials:

3-(4-Hydroxy-but-2-ynyloxy)-1,4-bis-(4-methoxy-benzyl)-piperazine-2,5-dione

1,4-bis(p-methoxybenzyl)-3-methoxy-2,5-piperazinedione

1,4-bis(4-methoxybenzyl)-3-(but-3-en-1-yloxy)piperazine-2,5-dione

(Z)-1,4-bis(p-methoxybenzyl)-3-(4'-hydroxy-2'-butenoxy)-2,5-piperazinedione

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