Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

Base Information

Chemical Name:Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate
CAS No.:328945-97-7
Molecular Formula:C₂₅H₂₂O₈S
Molecular Weight:482.511
Hs Code.:

Synonyms:Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

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Chemical Property of Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

Chemical Property:

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Technology Process of Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

There total 17 articles about Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 328945-88-6
2-Acetoxy-2',4-dimethoxy-4'-(tosyloxy)diphenylacetylene

: 328945-97-7
Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

Guidance literature:: With sodium acetate; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; at 20 ℃; for 48h;
DOI:10.1039/b006623k

Reference yield:

: 6626-15-9
4-Bromoresorcinol

: 328945-97-7
Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / acetone / 21 h / Heating

2: 15.0 g / acetone / 3 h / Heating

3: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C

4: 98 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 20 °C

5: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

6: 96 percent / CuI; i-Pr₂NH / PdCl₂(PPh₃)2 / dimethylformamide / 1.5 h / 60 °C

7: 71 percent / K₂CO₃; CuCl₂*2H₂O; NaOAc / PdCl₂(PPh₃)2 / 48 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; sodium acetate; potassium carbonate; triethylamine; diisopropylamine; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetone; 4: Sonogashira reaction;
DOI:10.1039/b006623k

Reference yield:

: 494773-45-4
4-bromo-3-hydroxy-phenyl 4-methyl-benzenesulfonate

: 328945-97-7
Methyl 6-methoxy-2-[2-methoxy-4-(tosyloxy)phenyl]benzo[b]furan-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 15.0 g / acetone / 3 h / Heating

2: 94 percent / KI; CuI / hexamethylphosphoric acid triamide / 3 h / 150 °C

3: 98 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / dimethylformamide / 1 h / 20 °C

4: 99 percent / TBAF / tetrahydrofuran / 0.17 h / 20 °C

5: 96 percent / CuI; i-Pr₂NH / PdCl₂(PPh₃)2 / dimethylformamide / 1.5 h / 60 °C

6: 71 percent / K₂CO₃; CuCl₂*2H₂O; NaOAc / PdCl₂(PPh₃)2 / 48 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; sodium acetate; potassium carbonate; triethylamine; diisopropylamine; potassium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetone; 3: Sonogashira reaction;
DOI:10.1039/b006623k